Thursday, 28 October 2021

Covishield and Covaxin mixing can give more pleasing results: ICMR

Covaxin and Covishield mixing can give more pleasing results: ICMR

The ICMR has revealed that a mix of Covishield and Covaxin, the two primary vaccines of India's Covid vaccination program, can yield better results, news agency ANI reported. The study runs on 18 people of Uttar Pradesh's Siddharth Nagar, who received two doses of two separate vaccines by mistake.

As per a study, which is yet to be reviewed, immunization with a combination of an adenovirus vector-based vector-based vaccine, followed by an inactivated whole virus vaccine, was safe.

Pune's Serum Institute of India manufactures Covishield, which is the adenovirus vector platform-based vaccine. Covaxin is manufactured and developed by Bharat Biotech, and ICMR is the whole virus vaccine. Covishield and Covaxin belong to two different types.

The study titled 'Serendipitous Covid-19 Vaccine-Mix in Uttar Pradesh, India: Safety and Immunogenicity Assessment of a Heterologous Regime' has been uploaded on medRxiv.

Under this study, 18 people received two doses of two different vaccines, which was compared to 40 recipients of two amounts of Covishield and 40 recipients of two doses of Covaxin, news agency PTI reported. The study duration was from May to June 2021, it said.

The mixing of vaccines is being discussed globally; all studies favor mixing two vaccines to increase the protection against future infection. The subject expert committee of the Central Drugs Standard Control Organisation has in July recommended a trial of mixing Covishield and Covaxin, which will be conducted by the Christian Medical College in Vellore on 300 healthy volunteers.

Covaxin and Covishield mixture can give finer results ICMR 1getty image

Read More: The study says the long gap in shots for Pfizer-BioNTech covid vaccines boost antibodies

While that will be a proper clinical trial to investigate the effectiveness of the cocktail of Covishield and Covaxin, the ICMR's study was based on the blunder that took place in May. There was no immediate adverse impact of the mix-up of the beneficiaries.

Further study has revealed that the mix-up has worked in favor of protection as these people have more protection than those who have received two shots of the same vaccine.

Mixing vaccines is sensitive as World Health Organization has warned that individuals should not decide on combining vaccines. Niti Aayog member (health) Dr. VK Paul had earlier said that theoretically, there is no problem in mixing two vaccines as the second dose in such a case will work as a booster shot.

But as the government started its vaccination drive on January 16, it asked health workers to exercise extreme caution to ensure that the beneficiaries receive the second shot of the same vaccine that they received as their first shots.

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