Thursday, 20 January 2022

The study says the long gap in shots for Pfizer-BioNTech covid vaccines boost antibodies

The study says the long gap in shots for Pfizer-BioNTech covid vaccines boost antibodies

It is one of the most comprehensive research into the immune response generated by the jab.

A more extended slot between the first and second jab of Pfizer-BioNTech COVID-19 vaccine generates potent antibodies and T cell immune reaction, found by UK researchers.

The study, guided by the University of Oxford, in partnership with the Universities of Birmingham, Liverpool, Sheffield, Newcastle and supported by the UK Coronavirus Immunology Consortium, is one of the most comprehensive immune response studies by the Pfizer vaccine.

The Protective Immunity T cells to Covid-19 in Health workers study' found that T cell levels are well-sustain and antibody levels are higher following a longer gap between the first and second Pfizer Covid-19 vaccine dose, despite a significant drop in antibody levels between doses.

The studies worldwide show that both the short and long dosing schedules lead to solid real-world protection against the Covid-19 virus, emphasizing the importance of having a second dose of the vaccine.

Dr. Thushan de Silva said, study author Senior Clinical Lecturer Infectious Diseases at the University of Sheffield.

Our study shows the value of examining both antibody and T cell reaction following the SARS-CoV-2 vaccine, primarily to understand multiple protection mechanisms against new covid Variants.
The study says the long gap in shots for Pfizer BioNTech covid vaccines boost antibodies 1getty image

Read More: 80% New COVID-19 cases accounts to Delta variant: Govt Expert Chief

Silva said: The longer gap interval that the UK has adopted appears to result in higher antibody levels after the second jab when compared to the shorter gap. However, there is an essential drop in antibody levels during the stretch interval while T cell responses are well-maintained. What is very clear is that two dosages are required to maximize protection, particularly against the new Delta mutant,

The research found that overall T cell, a different variant of immune cell, levels were 1.6 times lower with a long interval compared with a short dosing plan of 3-4 weeks,
But that higher proportion were "helper" T cells with a long gap, which support long-term immune storage.

The survey of 503 healthcare workers published on Friday found that longer dosing intervals resulted in higher neutralizing antibody levels, after the second dose, against the Delta variant and all other Variants of Concern tested.

It found that following two vaccine doses, neutralizing antibody levels were twice as high after the longer dosing interval than the shorter dosing gap.

Regardless of the dosing plan, the study found levels of antibodies and T cells mixed significantly from person to person, depending on genes, primary health conditions, and past detection to COVID-19 and other diseases.

Our study gives reassuring evidence that both dosing schedules generate robust immune responses against SARS-CoV-2 after two doses. For the more extended program, the antibody levels dropped off between first and second dose, which included the loss of any neutralizing effect against the Delta variant," said Dr. Rebecca Payne, study author from Newcastle University.

However, T cell responses were inline, indicating they may contribute to crucial protection against SARS-CoV-2 during this time, Payne said.

After the second dose on the more extended dosing schedule, antibody levels surpassed those seen simultaneously after a shorter dosing interval. Although T cell levels were comparatively lower, T cells' presentsprofile suggested more support of immune memory and antibody generation. Payne said we now need to carry out more follow-up studies to understand our findings' full clinical significance.

This work is the result of significant teamwork. The research would not have been possible without the partnership between researchers across five universities. It has allowed us to bring clinical force together and conduct one of the most in-depth analyses of immune response to a COVID-19 vaccine yet, said Professor Susanna Dunachie, PITCH study lead from the University of Oxford.

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